Jessee is now almost 21 months a Tripawd and is a ten year old great dane. She is on her third battle with cancer, all different types. We are currently taking an oral chemo that she is tolerating very well and seem to have the lung nodule under control. However, we have a behavioral issue we are not able to resolve yet. It’s now happening every night after she has had dinner. Everything is calm, no strange noises (sometimes a text alert on TV will start it, sometimes not). All of a sudden she will start panting, shaking and become very aggressive with her from foot. She attempts to “hit” my husband or myself. Nothing calms her down. She has had Xanax, Gabapaten and combination 0f the two. Neither works consistently. We try taking a walk, going outside, holding her, brushing her, attempting to distract her. Makes no difference. Recently we decided to try a “knock out” pill Acepromazine 25 mg. It works. One night we felt she needed two and it was too much. One 25 mg seems very effective for the time being. Fingers crossed. After taking the pill within about ten minutes panting, shaking stops. The episode is over and she will go get in one of her two beds and sleep for several hours. I’m trying to understand what is this. Our fabulous vet is reaching out within her community of behavior vets to see if they have seen similar behaviors and encouraged me to reach out here to Tripawds forum. No one else seems to have seen this in Danes before. Other than these nightly episodes she appears to be doing very well. Gained another pound. Eats almost every meal, more picky about lunch. 
This was Jessee last night with “dad” in recovery mode from an episode
Would really, really appreciate any feedback from anyone … thanks so much